TALKING TO YOUR DOCTOR

TALKING TO YOUR DOCTOR

QUESTIONS TO ASK YOUR DOCTOR

Your doctor is the best source of information if you have questions about your hairy cell leukemia or treatment. It is important to discuss any questions or concerns you may have with your doctor.

If you have been prescribed LUMOXITI, here is a list of questions you may want to ask during your next visit:

  • How many cycles of LUMOXITI will I need?
  • How long will each infusion take?
  • What other tests will I need?
  • How will my progress be monitored?
  • What side effects can I expect?

Before you receive LUMOXITI, tell your doctor about all your medical conditions, including if you:

  • Have had conditions that affect your blood and blood vessels called hemolytic uremic syndrome (HUS) or severe thrombotic microangiopathy (TMA)
  • Have kidney problems
  • Are pregnant or plan to become pregnant. LUMOXITI may harm your unborn baby
    • If you are a female who can become pregnant, you should use effective birth control during treatment with LUMOXITI and for at least 30 days after your last dose of LUMOXITI
    • If you are a female who can become pregnant, your healthcare provider will perform a pregnancy test before you start treatment with LUMOXITI
    • Tell your healthcare provider right away if you become pregnant during treatment with LUMOXITI
  • Are you breastfeeding or plan to breastfeed? It is not known if LUMOXITI passes into your breast milk. You and your healthcare provider should decide if you will receive LUMOXITI or breastfeed. You should not do both

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Know the medicines you take. Keep a list of your medicines with you and show it to your healthcare provider when you get a new medicine.

FREQUENTLY ASKED QUESTIONS ABOUT LUMOXITI

How is LUMOXITI given?

Each dose of LUMOXITI is infused into a vein (intravenously) over 30 minutes.

  • You will receive LUMOXITI on Days 1, 3, and 5 of each treatment cycle
  • Each treatment cycle is made up of 28 days, and you may receive up to a total of 6 treatment cycles
  • Your doctor will decide how many treatment cycles you need

How many cycles of treatment will I need?

You may receive up to 6 cycles of treatment with LUMOXITI. Your doctor will decide how many treatment cycles you need.

Why do I need to stay hydrated?

It is important for you to drink the additional prescribed amount of fluids during the first 8 days of each cycle when you receive infusions. This may help reduce the risk of serious side effects, including hemolytic uremic syndrome.

To help you stay hydrated throughout treatment, you can register to receive a free water bottle. Sign up here.

What is the most important information I should know about LUMOXITI?

LUMOXITI can cause serious side effects, including:

  • Capillary Leak Syndrome (CLS). LUMOXITI can cause fluid to leak from small blood vessels into your body’s tissues. This condition is called “Capillary Leak Syndrome” (CLS). CLS can quickly cause you to have symptoms that may become life-threatening if not treated right away. Get emergency medical help right away if you develop any of the following symptoms of CLS:
  • swelling of your face, arms, or legs
  • fast weight gain (increase in 5.5 pounds from Day 1 of your current cycle)
  • weakness or dizziness
  • shortness of breath or trouble breathing
  • cough
  • low blood pressure

Your healthcare provider will check your weight and blood pressure before you receive each dose of LUMOXITI and as needed during treatment.

  • Hemolytic Uremic Syndrome (HUS). Hemolytic uremic syndrome is a condition that affects your blood cells and kidneys and may be life-threatening if not treated right away. Get emergency medical help right away if you develop any of the following symptoms of HUS:
  • decrease in the amount of urine or dark urine (tea-colored)
  • unusual bleeding or bruising of your skin
  • stomach pain
  • vomiting
  • fever
  • feeling tired
  • changes in mood or behavior
  • confusion
  • seizures
  • shortness of breath
  • fast heartbeat

Your healthcare provider will do blood tests to check your blood cells and kidneys before you receive each dose of LUMOXITI and during treatment as recommended by your healthcare provider.

If you develop any of these symptoms of CLS or HUS, your healthcare provider may monitor you in the hospital.

Getting medical treatment right away may help keep these problems from becoming more serious.

Your healthcare provider will check you for these problems during your treatment with LUMOXITI. Your healthcare provider may delay or completely stop treatment with LUMOXITI if you have severe side effects.

See “What are the possible side effects of LUMOXITI?” below for other side effects of LUMOXITI.

What are the possible side effects of LUMOXITI?

LUMOXITI can cause serious side effects, including:

See “What is the most important information I should know about LUMOXITI?”

  • Kidney problems. LUMOXITI may cause kidney problems. People who have HUS, are 65 years of age or older, or those who have kidney problems before starting treatment with LUMOXITI may have an increased risk of worse kidney problems after treatment with LUMOXITI. Tell your healthcare provider right away if you have any changes in the amount you urinate. Your healthcare provider will do tests to check your kidneys before you receive each dose of LUMOXITI and as needed during treatment. Your healthcare provider may delay your treatment with LUMOXITI if you have severe kidney problems
  • Infusion reactions. LUMOXITI can cause infusion reactions that are common but can also be serious. Infusion reactions may happen on the day you receive your LUMOXITI infusion. Signs and symptoms of infusion reactions may include:
  • Chills
  • Cough
  • Dizziness
  • Shortness of breath or wheezing
  • Feeling hot or flushing
  • Fast heartbeat
  • Headache
  • Changes in blood pressure
  • Muscle pain
  • Nausea
  • Fever
  • Vomiting

Your healthcare provider may give you medicines to take before and after each LUMOXITI infusion.

  • Electrolyte problems. Tell your healthcare provider if you get any of the following symptoms of electrolyte problems:
  • Muscle cramps
  • Numbness or tingling
  • Abnormal or fast heartbeat
  • Nausea
  • Seizures

Your healthcare provider will do blood tests to check your electrolytes before you receive each dose of LUMOXITI and during treatment as recommended by your healthcare provider.

The most common side effects of LUMOXITI include:

  • Swelling in your face, arms, or legs
  • Nausea
  • Feeling tired
  • Headache
  • Fever
  • Constipation
  • Low red blood cells (anemia)
  • Diarrhea

These are not all the possible side effects of LUMOXITI.

Call your doctor for medical advice about side effects. You may report side effects related to LUMOXITI by clicking here.

What should I do if I experience serious side effects?

Get emergency medical help right away if you develop any of the following symptoms of CLS or HUS:


If you develop any of these symptoms of CLS or HUS, your doctor may monitor you in the hospital. Getting medical treatment right away may help keep these problems from becoming more serious. Your doctor will check you for these problems during your treatment with LUMOXITI. Your doctor may delay or completely stop treatment with LUMOXITI if you have severe side effects.