RECEIVING LUMOXITI

RECEIVING LUMOXITI

HOW DO I RECEIVE LUMOXITI?

Each dose of LUMOXITI is infused into a vein (intravenously) over 30 minutes.

  • You will receive LUMOXITI on Days 1, 3, and 5 of each treatment cycle
  • Each treatment cycle is made up of 28 days, and you may receive up to a total of 6 treatment cycles
  • Your doctor will decide how many treatment cycles you need

Your doctor will give you medicines and intravenous fluids before and after your infusions.

Be sure to stay hydrated!

It is important for you to drink the additional recommended amount of fluids during the first 8 days of each cycle when you receive infusions. This may help reduce the risk of serious side effects, including hemolytic uremic syndrome.

  • 3 liters is the same as drinking approximately twelve 8-oz glasses of water every 24 hours
  • 2 liters is the same as drinking approximately eight 8-oz glasses of water every 24 hours

WHAT WILL BE CHECKED BEFORE EACH DOSE OF LUMOXITI?

Before you receive each dose of LUMOXITI, tests will be performed to check your health and check for any side effects. These tests may include:

Measuring your weight

Measuring your blood pressure

Taking blood to count blood cells and check how well your kidneys are working

WHAT WILL I RECEIVE BEFORE EACH DOSE OF LUMOXITI?

Your doctor may give you certain treatments and medicines before each dose of LUMOXITI. These may include:

  • Intravenous fluids to help you stay hydrated
  • Medications to help prevent side effects such as allergic reactions, fever, or infusion reactions

WHAT WILL I RECEIVE AFTER EACH DOSE OF LUMOXITI?

After each dose of LUMOXITI, your doctor may prescribe the following:

  • Intravenous fluids to help you stay hydrated
  • Medications to help prevent side effects such as allergic reactions, fever, or nausea and vomiting. Only use these medications as directed by your doctor

Remember, it’s also important to drink the recommended amount of fluids on Days 1 through 8 of each treatment cycle.

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT LUMOXITI?

LUMOXITI can cause serious side effects, including:

  • Capillary Leak Syndrome (CLS). LUMOXITI can cause fluid to leak from small blood vessels into your body’s tissues. This condition is called “Capillary Leak Syndrome” (CLS). CLS can quickly cause you to have symptoms that may become life-threatening if not treated right away. Get emergency medical help right away if you develop any of the following symptoms of CLS:
  • swelling of your face, arms, or legs
  • fast weight gain (increase in 5.5 pounds from Day 1 of your current cycle)
  • weakness or dizziness
  • shortness of breath or trouble breathing
  • cough
  • low blood pressure

Your healthcare provider will check your weight and blood pressure before you receive each dose of LUMOXITI and as needed during treatment.

  • Hemolytic Uremic Syndrome (HUS). Hemolytic uremic syndrome is a condition that affects your blood cells and kidneys and may be life-threatening if not treated right away. Get emergency medical help right away if you develop any of the following symptoms of HUS:
  • decrease in the amount of urine or dark urine (tea-colored)
  • unusual bleeding or bruising of your skin
  • stomach pain
  • vomiting
  • fever
  • feeling tired
  • changes in mood or behavior
  • confusion
  • seizures
  • shortness of breath
  • fast heartbeat

Your healthcare provider will do blood tests to check your blood cells and kidneys before you receive each dose of LUMOXITI and during treatment as recommended by your healthcare provider.

If you develop any of these symptoms of CLS or HUS, your healthcare provider may monitor you in the hospital.

Getting medical treatment right away may help keep these problems from becoming more serious.

Your healthcare provider will check you for these problems during your treatment with LUMOXITI. Your healthcare provider may delay or completely stop treatment with LUMOXITI if you have severe side effects.

See “What are the possible side effects of LUMOXITI?” below for other side effects of LUMOXITI.

WHAT ARE THE POSSIBLE SIDE EFFECTS OF LUMOXITI?

LUMOXITI can cause serious side effects, including:

  • Kidney problems. LUMOXITI may cause kidney problems. People who have HUS, are 65 years of age or older, or those who have kidney problems before starting treatment with LUMOXITI may have an increased risk of worse kidney problems after treatment with LUMOXITI. Tell your healthcare provider right away if you have any changes in the amount you urinate. Your healthcare provider will do tests to check your kidneys before you receive each dose of LUMOXITI and as needed during treatment. Your healthcare provider may delay your treatment with LUMOXITI if you have severe kidney problems
  • Infusion reactions. LUMOXITI can cause infusion reactions that are common but can also be serious. Infusion reactions may happen on the day you receive your LUMOXITI infusion. Signs and symptoms of infusion reactions may include:
  • chills
  • cough
  • dizziness
  • shortness of breath or wheezing
  • feeling hot or flushing
  • fast heartbeat
  • headache
  • changes in blood pressure
  • muscle pain
  • nausea
  • fever
  • vomiting

Your healthcare provider may give you medicines to take before and after each LUMOXITI infusion.

  • Electrolyte problems. Tell your healthcare provider if you get any of the following symptoms of electrolyte problems:
  • muscle cramps
  • numbness or tingling
  • abnormal or fast heartbeat
  • nausea
  • seizures

Your healthcare provider will do blood tests to check your electrolytes before you receive each dose of LUMOXITI and during treatment as recommended by your healthcare provider.

The most common side effects of LUMOXITI include:

  • swelling in your face, arms, or legs
  • nausea
  • feeling tired
  • headache
  • fever
  • constipation
  • low red blood cells (anemia)
  • diarrhea

These are not all the possible side effects of LUMOXITI.

Call your doctor for medical advice about side effects. You may report side effects related to LUMOXITI by clicking here.